high performance computing on graphics processing units: hgpu.org

This paper introduces BioAgent Bench, a benchmark dataset and an evaluation suite designed for measuring the performance and robustness of AI agents in common bioinformatics tasks. The benchmark contains curated end-to-end tasks (e.g., RNA-seq, variant calling, metagenomics) with prompts that specify concrete output artifacts to support automated assessment, including stress testing under controlled perturbations. We […]

SMEs increasingly seek alternatives to cloud LLM APIs, which raise data privacy concerns. Dedicated cloud GPU instances offer improved privacy but with limited guarantees and ongoing costs, while professional on-premise hardware (A100, H100) remains prohibitively expensive. We present a systematic evaluation of NVIDIA’s Blackwell consumer GPUs (RTX 5060 Ti, 5070 Ti, 5090) for production LLM […]

Contemporary automated scientific discovery has focused on agents for generating scientific experiments, while systems that perform higher-level scientific activities such as theory building remain underexplored. In this work, we formulate the problem of synthesizing theories consisting of qualitative and quantitative laws from large corpora of scientific literature. We study theory generation at scale, using 13.7k […]

As large language models (LLMs) move from research to production, understanding how inference engines behave in real time has become both essential and elusive. Unlike general-purpose engines such as ONNX Runtime, today's LLM inference systems offer little operator-level visibility, leaving developers blind to where time and resources go. Even basic questions — is this workload […]

The proliferation of Python DSLs for developing kernels has democratized GPU programming. While kernel development is now Python-native, performance analysis and optimization still rely on external tools and fragmented workflows. We introduce Nsight Python, a Python profiling toolkit that bridges this gap by bringing performance analysis for GPU kernels into the Python ecosystem. Nsight Python […]

The rapid expansion of Transformer-based large language models has dramatically increased the need for high-performance GPUs. As a result, there is growing demand for fast, accurate, and widely generalizable GPU performance models to support next-generation hardware selection and system-level exploration. However, current data-driven methods are limited, exhibiting poor generalization across hardware and inadequate modeling of […]

GPU code optimization is a key performance bottleneck for HPC workloads as well as large-model training and inference. Although compiler optimizations and hand-written kernels can partially alleviate this issue, achieving near-hardware-limit performance still relies heavily on manual code refactoring and parameter tuning. Recent progress in LLM-agent-based kernel generation and optimization has been reported, yet many […]

The performance of modern AI systems is fundamentally constrained by the quality of their underlying kernels, which translate high-level algorithmic semantics into low-level hardware operations. Achieving near-optimal kernels requires expert-level understanding of hardware architectures and programming models, making kernel engineering a critical but notoriously time-consuming and non-scalable process. Recent advances in large language models (LLMs) […]

The combination of verifiable languages and LLMs has significantly influenced both the mathematical and computer science communities because it provides a rigorous foundation for theorem proving. Recent advancements in the field provide foundation models and sophisticated agentic systems pushing the boundaries of formal mathematical reasoning to approach the natural language capability of LLMs. However, little […]

High-performance attention kernels are essential for Large Language Models. This paper presents analysis of CuTile-based Flash Attention memory behavior and a technique to improve its cache performance. In particular, our analysis on the NVIDIA GB10 (Grace Blackwell) identifies the main cause of L2 cache miss. Leveraging this insight, we introduce a new programming technique called […]

Modern AI models demand high-performance computation kernels. The growing complexity of LLMs, multimodal architectures, and recommendation systems, combined with techniques like sparsity and quantization, creates significant computational challenges. Moreover, frequent hardware updates and diverse chip architectures further complicate this landscape, requiring tailored kernel implementations for each platform. However, manual optimization cannot keep pace with these […]

With the rapid progress of deep learning and large language models (LLMs), companies now spend enormous sums executing GPU kernels. These kernels have, therefore, become prime targets for aggressive optimization. Recent efforts increasingly leverage LLMs to generate GPU kernels, but make no formal guarantees about the generated kernels. We present the first equivalence checker for […]